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Anyone taking Effexor AND WELLBUTRIN XL...PLEASE tell me your story!
August 8, 2005
2:58 am
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ACryForHelp
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Hello all!

I am currently on one 300mg Wellbutrin XL & one 150mg Wellbutrin XL a day (total of 450mg per/day) & I seem to still have a lot of bad 'break through' symptoms & after speaking with a friend I haven’t spoken with in many years I am considering taking the same combination as her. We have rather similar ‘Issues’ & she has described the same ‘break through’ symptoms that I have as the reason that her doctor recommended this combination.

I have also been told that 450mg a day is a rare and rather high dosage for Wellbutrin XL & so I am worried about like liver/kidney problems.

I am just concerned because I thought that Wellbutrin XL was a Multiple Reuptake Inhibitor affecting DOPAMINE AND NOREPINEPHERINE & Effexor was a Multiple Reuptake Inhibitor affecting SEROTONIN AND NOREPINEPHRINE…

So that means that BOTH drugs boost the levels of Norepinephrine in the brain and I can’t find any information about what really high levels of this brain chemical do or why it would be good OR bad…

I tried to search at http://www.ask.com for “Effexor And Wellbutrin XL” and I only got 1 site that was a Blog for a woman asking this same question with 1 response from another woman who ‘kinda likes it’.

THE OTHER LINKS I TRIED TO OPEN INSTALLED A WORM AND A TROJIN VIRUS ON MY COMPUTER!!! SO PLEASE DON’T SEARCH THESE TERMS!!!

They seemed like real sites but when the page loaded it asked to install something – which I denied – but my Norton AntiVirus caught them and deleted them before they could do any damage!!!

SO PLEASE BE CAREFUL WHAT YOU SEARCH!! I never thought that someone would be SUCH an asshole that they would Spike HEALTH SITES!

This happened THREE TIMES before I gave up my search and came here to ask you guys!

So if you are taking this combination, or a combo involving either of them with something else, I would GREATLY appreciate it if you could tell me:

1. What you have been diagnosed with
2. What other drugs you have tried
3. If THESE are working for you
4. Primary side effects of either/or either of these drugs

My primary concern side effect wise is the Sexual Side Effects and Weight Gain…but any other one’s, POSITIVE OR NEGATIVE, would be greatly appreciated!

MY BREAK THROUGH SYMPTOMS INCLUDE:
Urges to hurt/burn/cut myself.
Total and Utter Hopelessness leading to being >< this close to trying to kill myself again. (8th time in total if I try again…) Apathy, poor concentration, & inability to make decisions. Sleep disturbances/nightmares. Irrational moods/defensiveness to the slightest criticism. General mood swings. And what I want MOST OF ALL: Do you think, in your OWN PERSONAL OPPINION, that Effexor & Wellbutrin XL MIGHT help me? Thank you very much!

August 8, 2005
1:18 pm
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ACryForHelp
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Anyone? Anyone?

I NEED ADVICE so I'm gonna post this responce to get it back to the top of the list so more people can see it...

Thanks!

August 8, 2005
1:37 pm
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fantasyland
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Acryforhelp,
I don't have any answers for you, but I'm waiting to hear what people say as well. I'm on 300mg of WellbutrinXL as well, and quite frankly, I think it's made me worse! In fact, I'm calling my doctor as soon as I write this so she can ween me off of it.
I've been on Zoloft, Paxil, and Prozac. I've never felt any effects from any of them. The only effects I can remember is when going off Paxil, it was terrible! I felt like I was in the twilight zone for days!!
The Wellbutrin just makes me angry and out of it.
I'll keep checking back too, to see if anyone responds.
Fantasyland

August 8, 2005
2:28 pm
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kathygy
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I have never taken wellbutrin and have different symptoms than you have. But I take 375 mgs of effexor for depression and ocd. It is an enormous help to me. I don't have any side effects except that its harder for me to cry. No weight gain or anything. I hope you find the help you need.

love,
kathy

August 8, 2005
3:23 pm
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michigangirl
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A Cry for Help:

I was on Effexor for a couple of years for depression. During that time, I gained 80 lbs. All I wanted to do was eat and I couldn't help it; I always felt hungry! I was also always tired and very aggressive towards family and friends. If I missed a dose, I started going through withdrawl and it was soooo horrible that I had to take a pill or I was sick---literally. If I took my dose late or missed a dose, I got what is referred to as "head tremors" where it feels like your brain is sloshing around in your head. Then when I took my pill, it went away. I also sweat a lot on Effexor, and was always hot.

I hated the way I felt on this med, so I decided to get off of it. It was NOT easy. I had head tremors for weeks, and felt like I had the flu, but it eventually went away. Three years later, I have lost all of the weight I gained from being on it. I also did some research online, and many people have had similiar experiences with Effexor, mostly bad. I bumped into a petition to take it off of the market because of all the horrible side effects. This drug is ADDICTIVE. Your body will not let you wean off of it easily. If you type in "head tremors from Effexor" on google.com, you will find that others have these symptoms. It's very scary and it really sucks. Overall, NO I don't think this med will help you. I think it'll hinder you more than anything.

August 8, 2005
4:09 pm
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healedinmaryland
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I take 300mg of wellbutrin and now down to 150mg of effexor per day. both ae sustained released. The combination has worked well for me and I have been on the combination for over 3 years. But now I am coming off the effexor gradually and will most likely be off it by the end of the year. I have never had any side effects from either of these drugs and the combination has worked extremely well for me. I have no qualms about taking meds as they have probably saved my life and now I have a fantastic attitude and great outlook on life. In fact I no longer have any symtoms of depression or anxiety. I do encourage you to meet with your doctor and finds what works best for you. Each individual is different, but without having doctor input you are just guessing and that can be dangerous.

August 8, 2005
4:20 pm
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ACryForHelp
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I did the Paxil thing a few years back and THAT made me worse...AND numb from the neck down...

My General Prac. gave me about 4 month's worth of samples and said "go find another doctor to perscribe it for you" then refused to give me any more samples OR a perscription when I ran out and couldn't get an appointment with anyone else...

I have been told that I am lucky to be alive and should have sued since just stop taking it not only almost made me get into many car accidents to & from school but also could have just flat out made me die.

The withdrawal was HORRIBLE and not only did I feel horrible for like a week but my X just sat there at the computer telling me that "everyone I talked to said that Paxil is non addictive...where is my dinner?"

I was also on Dep-a-coat (Don't remember how to spell it) and THAT made me ANGRY and almost VIOLENT AND I had to get a blood test every month to make sure it wasn't making my kidney's shut down or something horrible... I weened myself off of THAT.

The Wellburtin XL is Kinda working but I know that it SHOULD be working better...I shouldn't be wanting to kill myself all the time!

I mean, don't get me wrong...I like the Wellbutrin XL. It is helping with my smoking and I have no sexual side effects but I am on it to stay alive not quit smoking...that is just a bonus!

Any other recomendations on what I could mix with the Wellbutrin XL that might make it work better?

PLEASE share your med stories!

Thanks!

August 9, 2005
5:32 pm
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hoping_2_feel_again
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I am taking Wellbutrin XL for depression and weightloss. I haven't had any adverse side effects. It has helped me not to be so hungry all the time (and I have lost weight, my sex drive improved as has my ability to remain somewhat calm in stressful situations.

I was taking both Paxil and Welbutrin for several months and was a total basketcase. When I dropped the Paxil, things got much better.

Soooo....it has worked for me, but I do think your body chemistry might make it affect different people differently.

August 9, 2005
11:53 pm
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ACryForHelp
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Thanks...I'm finding out that either you LOVE the combo or HATE IT TO THE POINT OF SCREAMING!

I guess it can't hurt to try the combo...I'v delt with Depacote that made me almost violent & paxil withdrawl...I can deal with the Effexor if it starts to mess with me.

It can't be worse then those ^ two.

Thanks for shareing!

Night!

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